Warning: Don't be fooled by copy cat companies who advertise with our name and have taken original content from our website. Their "knock off" products have nothing to do with our #1 rated, proven Prostate Formula, which has given thouands of men the relief they seek for prostate discomfort. This website is the only source for the authentic Prostate Miracle®

The Prostate: Its Function and Diseases

The prostate is a gland of the male reproductive system about the size and shape of a walnut. Located in front of the rectum, it wraps around the urethra (the tube that carries urine from the bladder out through the tip of the penis). The Prostate's main function is to produce fluid for semen, which transports sperm.

Chances are, if you are visiting this site... You or someone you know is suffering from a prostate problem.

The most common symptoms include:

Difficulty initiating urination
Weak urinary stream
Frequent urination often with urgency and/or often accompanied with incontinence
Waking several times at night to urinate
Sexual dysfunction and decreased libido

The most common symptoms include:

Bening porstatic hyperplasia (BPH) read below
Prostatitis read below
Prostate cancer read below

BPH is a non-cancerous enlargement of the prostate. Symptoms result when the enlargement squeezes the urethra where it runs through the prostate. BPH is the most common of prostate conditions among men. It is more common among older men, because as a man ages, his prostate naturally enlarges. Starting at about age 40, levels of a hormone called prolactin begin increasing in men, this stimulates an increased production of the enzyme 5-alpha reductase. This in turn increases the metabolism of testosterone, resulting in an increase of the metabolic byproduct di-hydro-testosterone or DHT. DHT is very unhealthy and has the undesirable effect of stimulating prostate cells into dividing and multiplying which causes the prostate enlargement. More than 50 percent of men age 60, and 80 percent of men age 80, are estimated to suffer from BPH. It is important to note that BPH does not necessarily lead to cancer; however, a man can have BPH and cancer at the same time.

Prostatitis is an inflammation of the prostate. It is not contagious. Postatitis is a mysterious ailment and most urologists will admit that, though in some cases they do understand its cause, many times they do not. Prostatitis is sometimes caused by bacteria similar to those which cause other types of urinary infections. Some patients however, have no evidence of bacteria in their prostates yet are thought to carry microorganisms such as Chlamydia or Ureaplasma, which are harder to identify by standard culture techniques. Still other patients have no evidence of any microorganisms at all. This makes it very difficult to diagnose and treat. Many urologists will "blindly" prescribe antibiotics, which seldom work, It is important to note that prostatitis sometimes develops from untreated BPH.

Prostate cancer is a malignant tumor that most often begins in the outer part of the prostate. As the tumor grows, it may spread to the inner part of the prostate. Treatment options for prostate cancer include watchful waiting, hormonal therapy, radiation, brachytherapy and surgery.

Two tests critical to detecting men at higher risk of prostate cancer and other prostate diseases are the digital rectal exam (DRE) and the prostate-specific antigen test (PSA test). A high PSA can indicate a greater chance of developing prostate cancer. However, a high PSA does not necessarily mean cancer is present; many men with BPH also have elevated PSA levels.

Prostate Facts

Almost 30 million men suffer from benign prostatic hypertrophy (BPH).
Odds are 2 to 1 you'll have prostate problems by the time you are 60.
Each year over 400,000 men in the United States alone undergo prostate surgery; and over a billion dollars a year is spent on prostate treatment.
Surgery often results in incontinence and impotence.
Proscar, the leading pharmaceutical drug for treating prostate problems, is highly dangerous; and according to the U.S. Veteran's Administration is no more effective than sugar pills.
Saw palmetto is not an effective treatment for an enlarged prostate because it has a low concentration of beta sitosterol.
Prostate Miracle® is 3,000 times more powerful than saw palmetto.
Prostate Miracle® is 95% effective in treating an enlarged prostate.

Are you ready to wear diapers and/or never have sex again?

Fortunately, BPH sufferers do not have to resign themselves to such a drastic outcome. Nature has given us a natural remedy to support good prostate health.

Prostate Miracle® is a Natural, Highly Effective Treatment for BPH

Numerous international scientific journals have published scientific studies that prove that beta-sitosterol is the most effective remedy known for prostate problems. Beta-sitosterol is already in our diet in common foods we eat every day but only in small amounts. It is completely safe and without side effects.

Prostate Miracle is formulated using US produced beta-sitosterol (extracted from soy). Each 100% vegetable capsule of Prostate Miracle contains 300 mg of beta-sitosterol, making it 3,000 times more potent than saw palmetto. You would have to eat 2 lbs. of saw palmetto berries to get the same amount of beta-sitosterol that Prostate Miracle® provides in ONE capsule.

Prostate Miracle® is effective in 95% of patients... WITH NO SIDE EFFECTS.

Prostate Miracle® combines the 4 most important natural nutrients for promoting prostate health (in the correct amounts to be effective) 300 mg of Beta-Sitosterol with 7.5 mg of Zinc, 100 mcg of Selenium and 1000 iu's of Vitamin D3.
Prostate Miracle® is effective in 95% of patients, significantly decreasing the
prostate size while dramatically reducing BPH symptoms.
Prostate Miracle® is effective in relieving BPH induced Prostatitis.
Prostate Miracle® is effective in lowering PSA levels.
Prostate Miracle® is an excellent pre-emptive measure to prevent prostate cancer from developing.
Prostate Miracle® is manufactured with pharmaceutical grade (USP) ingredients in the USA, in GMP Certified, FDA licensed and inspected facilities.

Prostate Miracle® May Help Prevent and Slow the Growth of Prostate Cancer

Each daily serving of Prostate Miracle® provides 200 mcg of selenium which is the same amount used in the numerous studies which have all confirmed the tremendous benefit selenium has in both treating and preventing prostate cancer. In fact it has been demonstratead that 200 mcg per day of selenium may actually reduce the risk of getting prostate cancer (by as much as 50%).

The benefit of selenium is not limited to prostate cancer. Other studies have shown that taking 200 mcg of selenium per day may actually protect against lung cancer & guard against colon cancer as well. Although the RDA for selenium is 70 mcg, most researchers agree this is a very conservative value... And that considerably higher doses are safe. There certainly aren't any published studies that indicate 200 mcg per day is harmful in any way.

How Does Prostate Miracle® Compare To Other Prostate Formulas?

There are other prostate formulas on the market. You may be interested to know how they compare to Prostate Miracle®.

First of all, Prostate Miracle® comes in a 100% vegetable capsule. How many others (if any) can say that?

Secondly, you've probably heard about those so-called super prostate formulas, that contain every ingredient under the sun . . . many of which you might already be taking . . . or which could potentially result in unwanted side effects or even allergic reactions.

The truth is that the most important ingredients in promoting better prostate health are beta-sitosterol, zinc, selenium and vitamin D3. Most other added ingredients are of no additional benefit.

Furthermore, if a prostate formula does not contain Beta Sitosterol. it is basically worthless. In fact it should provide 300-600 mg of beta sitosterol per day. The dose required for relief depends on the severity of the condition... Those suffering from a severe case should take 600 mg/day, while for those with a mild case or who simply want to prevent BPH... 300 mg/day is quite sufficient.

It is interesting to note that although some new formulas on the market now contain over 600 mg per daily serving... there is no evidence of any additional benefit from a daily dose greater than 600 mg.

It does beg the question... Why would any reasonable person take a product which provides a larger dose than they need? Or
which provides ingredients they don't need at all?

Prostate Wars

When we Prostate Miracle® in 2001, there were just a few other companies out there, who were producing prostate formulas. Since that time, this comparison page has served as a quick reference for comparing the prostate formulas made by these hand full of established companies. As new products have been introduced into the market place, we have done our best to quickly review them and update this page with info about how they compare to the other prostate products.

In recent years and even months... The "prostate formula" landscape has changed dramatically. Now the market is flooded with "copy cat" prostate products... And it has become more and more confusing for consumers to sort out the truth about which formula is best for them.

With so many "copy cat" products out there now... It's just not possible for us to keep updating this comparison page with every new product that hits the market... So we have decided to no longer review additional products for inclusion on this page.

There are however, several new "copy cat" companies that in our opinion are so unprofessional and unethical, that we feel obliged to discuss these companies and the "knock off" formulas they sell.

Best Prostate— Nature's Healthy Supplements, Inc, a relatively new company (established in 10/07), promotes their "knock off" product called "Best Prostate" as being both cheaper and stronger than Prostate Miracle®

First... Let's talk about this "copy cat" company.

Take a look at this page taken from their "best prostate" website (07/22/2008). They have shamelessly copied original content verbatim from our site to theirs... AND claimed copyrights for it. This is nothing short of blatant plagiarism.

Beware of this company...

Let's examine the claim they make... That their product has the strongest beta sitosterol available.

First of all— What is the point of bragging that their product has 10 mg more than Prostate Miracle®? It is such an insignificant amount more (only 3%).

Secondly— There is no evidence of any additional benefit from a daily dose greater than 600 mg... So why would anyone take a product which contains more?

Thirdly (and most importantly)— They lie about what they put in their product.

The makers of Best Prostate have been making the following false claim on their website: "Unlike other brands of Beta-sitosterol which often are a beta-sitosterol complex with only 55% actual beta-sitosterol. With Best Prostate you are assured 310 mg of actual beta-sitosterol as we take into account that our branded product source is 80% beta-sitosterol."
They go on to support this false claim, by showing a product spec sheet for a German made raw material, citing it as the source of the beta sitosterol contained in their product - Best Prostate.

This is an outright lie and contradicts other claims they make.

On one hand they claim to use US sourced BETA-SITOSTEROL.
Yet on the other hand, they also claim to use this German made raw material.
Which claim is true ? It clearly can NOT be both.

To see the actual proof of their blatant lies and false claims... Take a look at the following 2 pages taken from their Best Prostate website (10/28/2009).

Best Prostate - False Label Claims

Best Prostate - FAQ page - Lies

Another irregularity with Best Prostate is their label. It is totally non compliant with FDA labeling standards.

Their label claim of 15 mcg selenium per serving, incorrectly states that amount of selenium to be 50% Daily Value (it is actually 21% DV).
They also do not state the form of selenium used, so it is unclear if they provide 15 mcg of a selenium salt or of elemental selenium.
They also make the false label claim: "ALL NATURAL"
Best Prostate includes Zinc Citrate which is NOT natural. It is synthesized by combining citric acid with zinc oxide and Best Prostate includes Glyceryl Behenate which is NOT natural.
It is synthesized by combining glycerine with fatty acids.
All GMP certified labs are required to comply with the FDA labeling standard. So one wonders if Best Prostate is even produced in a GMP certified lab. With what we have uncovered about this unethical company. It seems doubtful.

The bottom line is that the makers of Best Prostate have grossly misrepresented their product and have proven themselves to be very dishonest and unethical

They have made false label claims.
They have lied about the ingredients Best Prostate contains.
They have plagiarized original content from our website.
They also claim to have the lowest price advertising $1 less per bottle than Prostate Miracle® but when you factor in their shipping charges it will probably end up costing more than the number one rated, proven Prostate Miracle® does.

It is hard to imagine why any reasonable person would buy a cheap "knock off" product, produced by a dishonest company that plagiarizes, makes false claims and lies about what they put in their product. Your health is way too important to take a chance with such a dishonest, highly unethical, "fly by night" company.

Update 10/29/2009:

In what appears to be a response to our exposure of the lies, absurd false claims and misrepresentations that the makers of Best Prostate have made.

They have removed from their website, the false statements they were making about the ingredients they supposedly used in their product. For your convenience we have archived their old web pages, so that you can still see them here:

Best Prostate - False Label Claims

Best Prostate - FAQ page - Lies

I would imagine that the makers of Best Prostate are squirming now scrambling and strategizing as to what they can do to recover from this very damaging exposure about their company and product.

They have added the following 3 statements to their website:

"We are constantly looking to improve our product and the ingredients that we use."
"Additional updated information will be forth coming with regards to a product data sheet."
"Almost all other beta-sitosterols have a maximum beta-sitosterol content of 55%". This statement is misleading and gives the false impression that the raw material they use has more than the "others."

In what seems to be a typical action for this highly unethical company, they are fighting back by spreading more vicious lies they have just published on the web, the following slanderous false statement about Prostate Miracle®: "Nature's Health Supply's original prostate product was a re-labeled Prostate Formula Dietary Supplement as endorsed and co-owned by Dr. Michael Teplitsky, M.D."

This, like many of things this company says or publishes, is a blatant lie. Prostate Miracle® has NEVER been a re-labeled Prostate Formula.

BUYER BEWARE. The makers of Best Prostate have plagiarized, lied, mislead and misrepresented their product!

HealthyChoiceNaturals— (aka MensHealthTech) produces a "knock off product" which they call "Prostate Care". They have deceptively promoted "Prostate Care" as a "new and improved Prostate Miracle®". An obvious ploy to trick people who are searching for the original Prostate Miracle®, by Your Health Supply.

Their price is significantly higher than Prostate Miracle® and some people have been fooled into thinking "new and improved" Prostate Miracle® it costs more it must be better.

This deception couldn't be further from the truth and has propagated lots of confusion in the marketplace, So let's set the record straight.

Your Health Supply and Prostate Miracle® are not related in any way, shape or form to HealthyChoiceNaturals and their "knock off" product Prostate Care.

In fact our legal department has served them papers demanding that they cease and desist from infringing on our registered Prostate Miracle® trademark. After many phone calls to their corporate office, and after many unfulfilled promises, finally they did comply, but just for a short while, and then commenced again (perhaps thinking that they could "get away with it" again using a different company identity). Ultimately, Google stepped in and forced them to stop their deceptive online advertising.

Beware of this company

But enough about their company. Let's look at their formula. It has 300 mg of beta sitosterol, that's good. It has zinc citrate , that's good too. But why do they provide 30 mg per serving ? That amount of zinc is way too much and could even be potentially dangerous.

Their product also contains some DIM (diindolymethane), that's a nice idea, DIM truly is a great supplement to take for prostate health. The problem is that clinical studies show you need to take 200 mg /day to get any benefit from it. Their product only provides 40 mg per caplet, which is not nearly enough. Taking DIM in such a small amount is basically worthless, it does not make their formula any more effective, just more expensive.

If there was a way to add 200 mg of DIM to Prostate Miracle® we would have, but it just didn't make sense to make Prostate Miracle® into a much larger pill or alternatively, to provide a product (as they did) which doesn't provide enough DIM to be effective.

That is why Nature's Health Supply, Inc formulated Estrogen Balance®, a companion product to Prostate Miracle® which provides 200 mg of DIM as well as Quercetin and Flaxseed.

It is also interesting to note that although HealthyChoiceNaturals sells Roger Mason's book "The Natural Prostate Cure" They must not have read it. As Roger clearly states Lycopene is a total fraud and has no place in a prostate formula.

Comparison of Prostate Products

Dr. Larry May promotes a prostate product on TV called Prosvent. It is rather expensive ($79.95 for a 60 day supply) and contains NO Beta Sitosterol what-so ever.

Physicians Choice also promotes a prostate product on TV called Super Prostate Formula. They have an "original" formula and a "new and improved" formula:

Their original formula contains 315 mg of Beta Sitosterol per 3 caplets (105 mg per caplet). Each bottle contains 90 caplets or 9,450 mg of Beta Sitosterol per bottle.
Their new formula contains 500 mg of Beta Sitosterol per 4 caplets (125 mg per caplet). Each bottle contains 120 caplets or 15,000 mg of Beta Sitosterol per bottle.

HerbDocs, LLC also promotes a product on TV called Prosta-Norm. Their formula has some Beta Sitosterol, but they don't tell you how much nor is there any mention as to the source (USA or China). It is priced at $39.95 per bottle which equates to 54% - 88% more expensive (depending on quantity ordered) than Prostate Miracle®.

Hampshire Laboratories produces a product called Prost-8. Their formula has 300 mg of Beta Sitosterol per caplet, but no mention is made of the source (USA or China). It is priced at $39.95 per bottle which equates to 54% - 88% more expensive (depending on quantity ordered) than Prostate Miracle®.

Merazon Health Products produces a product called Provelex. Their formula contains 400 mg of Beta Sitosterol per 3 caplets (133 mg per caplet). Each bottle contains 90 caplets or 11,970 mg of Beta Sitosterol per bottle.

Robert E. Wheeler MD promotes a product called Peenuts®. Their formula contains NO Beta Sitosterol what-so-ever.

Gold Canyon Products produces a product called Prostamax. Their formula contains Saw Palmetto & Golden rod extract but contains NO Beta Sitosterol what-so-ever.

Purity Products has a product called Ultimate Prostate Formula. Their formula contains some Beta Sitosterol, but only 60 mg. (not nearly enough)

Herbalife also has a a product called Ultimate Prostate Formula. Their formula contains NO Beta Sitosterol what-so-ever.

The Prostate Power Rx formula by Ray Sahelian, M.D. contains some Beta Sitosterol, but only 60 mg. (again, not nearly enough)

Each serving (1 vegetable capsule) of Prostate Miracle® contains: a whopping 300 mg of Beta-Sitosterol, 7.5 mg of Zinc, 100 mcg of Selenium and 1000 iu's of Vitamin D3.

Each bottle of Prostate Miracle® contains 60 vegetable capsules, providing 18,000 mg of Beta Sitosterol per bottle.

When you consider that Prostate Miracle® is priced lower than most of these others, there is just no other product that comes close to it's quality and value!

Not All Beta Sitosterol is created equally

Beta Sitosterol is found in nearly every vegetable we eat, as well in many herbs such as saw plametto, stinging nettles, pumpkin seeds etc. However, the concentration in most of these sources is very weak. It turns out that the best source for beta sitosterol is soy. Recent technological advances have led to cost effective methods for extracting highly concentrated, very pure beta sitosterol from soy.

These days, there is a wide range of beta sitosterol quality, purity and potency available. The majority of beta sitosterol complex is now being imported from China. Many of the newer prostate formulas out there, use the cheaper Chinese made beta sitosterol. Ever since the early 1980s when China first began competing in the raw materials sector of the U.S. nutrition industry, their quality control has come into question. Beta sitosterol and other raw materials exported from China are often contaminated with unacceptable levels of heavy metals or with the residues of herbicides or pesticides. Chinese beta sitosterol falls far below the standard we will accept for use in Prostate Miracle®. The excellent reputation Prostate Miracle® has enjoyed since 2001 is due in part to the high quality USA made beta sitosterol it has always contained.

Prostate Miracle® contains US made, pharmaceutical grade, 98% pure, phytosterols, which contain at least 50% beta-sitosterol. In addition, this includes 2-to-2.5% beta-sitostanols. Sitostanols are much more delicate than the sterols, and this is a good indication that the phytosterol complex has been properly extracted and is of the highest quality available.

There is a great deal of confusion in the market place in regards to the terms: Phytosterols, Beta Sitosterol and Beta Sitosterol complex. Much of this confusion is the result of some of new prostate formula companies promoting their formulas as having the "strongest" dose of beta sitosterol available.

In order to intelligently compare "apples to apples" it is important to clarify these terms used in the natural health industry. To set the record straight, Phytosterols (also known as plant sterols) are a group of steroid alcohols, which occur naturally in plants. Included in this group are the sterols: Beta Sitosterol, Campesterol, Stigmasterol, Brasicasterol; as well as the stanols: Campestanol and Stigmastanol. Of this group, Beta sitosterol is the one which has been shown to be so effective in treating BPH.

It is common in the natural health industry, when referring to this combined group of plant sterols and stanols to interchange the terms phytosterols and beta sitosterol complex. It is important to understand that beta sitosterol is just one (the most important) of the plant sterols and stanols included in the group.

The amount of beta sitosterol contained in any beta sitosterol complex will depend on both the natural balance of the source material as well as the purity of the phytosterols, which is based on the quality and precision of the extraction process. The beta sitosterol complex used in Prostate Miracle is 98% pure and contains 40-58% actual "free" beta sitosterol.

Saw Palmetto and Pygeum Africanum are Useless

In a recent article, world renown research chemist, Roger Mason says "For years now I've been explaining why saw palmetto, pygeum africanum, stinging nettles, pumpkin seeds and other similar herbs are useless, have no therapeutic effect, do not help prostate health in any way and are mere promotional scams. Yet, men keep buying countless millions of dollars worth of saw palmetto and other such worthless products every year.

And all of them are equally worthless because they contain such a low concentration of active ingredient beta sitosterol complex.

The Beta sitosterol used in Prostate Miracle® is literally two to three thousand times stronger than saw palmetto powder. This means you would have to eat two to three thousand capsules of saw palmetto powder to get an equivalent amount of beta sitosterol contained in one single capsule of Prostate Miracle®. What about the extracts, one might ask? The very, very best saw palmetto extracts are only ten to one extractions so you would still need to eat 200 to 300 capsules of saw palmetto extract. Notice what they say on the extract bottles, "contains 85% fatty acids and sterols". This means you get 99% fatty acids and maybe 1% sterols- if you're lucky.

Want proof of how useless saw palmetto and Pygeum africanum are? Here is a typical study published in the Gazzetta Chimica Italiana volume 118 in 1988 (page 823). Some chemists at the University of Milan extracted saw palmetto berries and submitted them to very extensive analysis. Mostly they found common fatty acids like we find in our everyday foods. They found very minor amounts of caratenoids, alcohols, polysaccharides and a tiny, tiny bit of beta-sitosterol complex. In fact they found a mere one part in 5,000 of beta-sitosterols or only one fiftieth of one per cent. This means in this batch of saw palmetto berries you would have to eat 5,000 capsules to get less than 500 mg of beta-sitosterols."

Saw Palmetto may actually be Harmful to your Prostate

Three recent scientific studies, surprisingly indicated that saw palmetto may actually harm your prostate health! These studies, which were investigating the effect of saw palmetto on prostate tissue all came to the same conclusion: Saw palmetto has an effect similar to chemotherapy on prostate cells - it kills both unhealthy and healthy cells!

One study published in Prostate (2000 Nov) examined the effect of saw palmetto on stroma cells (the framework cells that build supportive tissue) and on epithelial cells (those which line the glands and ducts of the prostate). The study was done on normal prostate tissue and on BPH tissues from patients treated with and without the saw palmetto. The conclusion was that saw palmetto damages the nuclear and mitochondrial membranes, and causes cellular death in the epithelium and stroma.

Another study published in the Journal of Urology (2000 Nov) investigated the effects of saw palmetto on primary cultures of fibroblasts (cells that produce connective tissue), and epithelial cells from the prostate, epididymis (the tube that provides for the storage, transmission and maturation of sperm), testes, kidney, skin and breast to determine if the action of saw palmetto is selective and specific to prostate tissue. This study concluded that saw palmetto caused damage and death in prostate tissue, though there were no similar changes observed in other types of cells.

A third study published in Prostate (1999 Sep) examined the effect of saw palmetto on benign prostatic hyperplasia (BPH). Again, the results showed there was widespread damage of intracellular membranes, including mitochondrial and nuclear membranes in both healthy and overgrown prostate tissue.

In light of this new information, it seems prudent to avoid saw palmetto as a treatment for BPH. It is possible that research may eventually show saw palmetto to be an effective way to kill prostate tumor cells, but its toxicity to healthy prostate cells is reason enough to be concerned about taking saw palmetto daily as a either a treatment or preventative measure for BPH.

Lycopene is a Fraud

Many Prostate Formulas contain lycopene and according to Roger Mason "Lycopene is a fraud, a hoax, a deceit and deception." Nearly every single "study" that has been published on lycopene has simply been a paid advertisement in a journal funded by and paid for by Lyco-Mato in Israel. This isn't science- it is advertising. If lycopene had any value scientists around the world would be using GENERIC lycopene in double blind studies to prove its value.

One recent article stated that blood studies of lycopene prove it is effective in treating prostate disease (Pure Appl. Chem. v. 74 in 2002). It turns out that they measured plasma lycopene levels. The only problem is that plasma does not carry lycopene. Only the blood serum absorbs the lycopene. Countless, proper serum studies of tens of thousands of men prove beyond any doubt that blood serum lycopene levels are completely unrelated to prostate health in any way, shape or form.

Ohio State University concluded in an extensive review (Pure Appl. Chem. v. 74 in 2002), "The consumption of lycopene supplements is not currently recommended for prostate cancer prevention or therapy".

The famous Hutchison Cancer Center (JNCI v. 92 in 2000) basically concluded lycopene is useless when it comes to prostate health.

Ed Giovannucci has been the biggest supporter of lycopene, but even he admits (Proc. Soc. Exp. Biol. Med. v. 218 in 1998), "However, it is premature to suggest that either tomatoes or lycopene is causally related to protection from prostate cancer or that the consumption of products rich in lycopene will have a beneficial effect for men suffering from established prostate cancer."

The Japan-Hawaii Cancer Center (Cancer Epidem. Biol. Prev. 6 in 1997) studied serum from 6,680 men and found it unrelated to prostate health.

The biggest of all studies from NIH and Johns Hopkins University (JNCI v.82 in 1990) studied the serum of 25,802 men and found no relation whatsoever with prostate health and lycopene levels.

We could go on all day with such studies to prove the lycopene is a useless promotion for profit but you get the idea by now.

Beta-Sitosterol Research

Beta-sitosterol is the miraculous common denominator found in saw palmetto, pygeum africanum, pumpkinseed oil and stinging nettles. However, the concentration of beta sitosterol in these herbs is very small . . . at best . . . a mere 3,000th of the amount found in Prostate Miracle®. Beta-sitosterol is also found in common foods we eat every day but in even smaller amounts than the above mentioned herbs. The chemical structure of beta-sitosterol is similar to that of cholesterol . . . the main difference being the presence of an extra ethyl group. Beta-sitosterol is completely safe and without any side effects.

Numerous international scientific journals (European Patent EP 287,2000; European Journal of Drug Metab., 1997; International Journal of Immunopharmacol, 1996; Anticancer Research, 1996; The Lancet, 1995; European Urology, 1994 and 1992; Minerva Urologia, 1985; British Journal of Clinical Pharmacology, 1984; Medizinische Klinik, 1982; and Fortsher. Med., 1980) have published scientific studies that prove beta-sitosterol is an extremely effective, natural treatment for an enlarged prostate.

Excerpts from the following article (published by: LE Magazine Special Edition, Winter 2005/2006) summarize the latest beta sitosterol research... all of which validate the amazing effectiveness beta sitosterol has a treatment for BPH and other prostate ailments.

Beta-Sitosterol and the Aging Prostate Gland

by Stephen B. Strum, MD, FACP, and William Faloon

Prostate disorders wreak havoc on the majority of aging men. Scientists have identified nutrients and drugs that alleviate symptoms of benign enlargement and reduce prostate cancer risk.

A plant extract called beta-sitosterol may be of particular benefit. Published studies indicate that beta-sitosterol consistently improves urinary symptoms related to prostate enlargement.

For the past several decades, European doctors have routinely prescribed a variety of plant-based drugs to treat benign prostate enlargement and lower urinary tract symptoms. Saw palmetto, pygeum, and nettle root extracts are common plant-based drugs prescribed to millions of men in Europe.

Consumers in the U.S. have open access to these same nutrients that are approved as drugs in Europe to combat urinary symptoms of benign prostate enlargement.

Beta-sitosterol is a plant fat contained in several European prostate drugs, though it is not routinely used in the United States. Multiple randomized studies have confirmed the efficacy of beta-sitosterol in alleviating the types of prostate discomfort that aging men so frequently encounter.

Measuring Symptoms of Prostate Enlargement

In order for scientists around the world to evaluate the efficacy of a particular therapy, certain testing standards have been established.

One of the most common standards is the International Prostate Symptom Score (IPSS). The score is stated as a number that can range from 0 to 35, depending on the severity of lower urinary tract symptoms. The International Prostate Symptom Score also includes a scoring of quality of life as it relates to urinary symptoms.

A measurement to assess the strength of the urinary stream is called the maximum urinary flow rate (Qmax). The maximum urinary flow is commonly decreased with benign prostate disease such as BPH (benign prostatic hyperplasia).

The third test is the amount of residual urine that remains in the bladder after voiding, or post-void residual urine (PVR). This is most easily assessed with pre- and post-void ultrasounds of the bladder.

Remarkable Effects of Beta-Sitosterol

Figure 1 - International Prostate Symptom Scores (IPSS): Beta-Sitosterol vs. Placebo.

Data comparing men treated with beta-sitosterol to those receiving placebo indicate a significant decrease in symptom scores in the beta-sitosterol group after three and six months of treatment. 3 In a follow-up study, these improvements were maintained for an additional 18 months of observation. 4

In a randomized, double-blind, placebo-controlled, multicenter study of 200 men with benign prostate enlargement, half the group received 180 mg of beta-sitosterol daily, while the other half received placebo.

After six months, the beta-sitosterol group saw improvement in the International Prostate Symptom Score, the measurement of urine flow (Qmax), and the amount of residual urine remaining in the bladder (PVR) 1

The beta-sitosterol group showed a 7.4-point decrease in the International Prostate Symptom Score, compared to a decrease of only 2.1 points in the placebo group. This was a significant 3.5-fold improvement in the men taking beta-sitosterol (Figure 1) 1

The measurement of urinary flow increased to an average of 15.2 milliliters (ml) per second from 9.9 ml/second in the men receiving beta- sitosterol. The placebo group only increased to 11.4 ml/second from 10.2 ml/second at baseline. Urinary flow thus improved almost 35% in the group taking beta-sitosterol, compared to only 11% in the placebo group 1

Most remarkably, residual urine in the bladder decreased to 30.4 ml from 65.8 ml in the men using beta-sitosterol ... a reduction of almost 54%! In the placebo group, residual bladder urine declined from 64.8 ml to 54.3 ml ... a reduction of only around 16%. 1

In a follow-up study that evaluated durability of response to beta-sitosterol, the beneficial effects for beta-sitosterol were found to be maintained during an additional 18 months of observation. 2

Figure 1 shows the significant difference in the International Prostate Symptom Score in men receiving beta-sitosterol compared to placebo.

Benefits of Beta-Sitosterol Confirmed

To confirm these remarkable effects of beta-sitosterol, another study was performed and the results were published in the British Journal of Urology. The study involved 177 patients with benign prostate enlargement. Patients received 130 mg of beta-sitosterol each day and were monitored for more than six months. Measurements of the International Prostate Symptom Score, urinary flow, and residual urine in the bladder after voiding were recorded. 3

On average, urinary flow values increased by 4.5 ml/second while residual urine volumes decreased by a substantial 33.5 ml. The International Prostate Symptom Scores showed a statistically significant improvement. These results with beta-sitosterol are comparable to those seen with the commonly prescribed drug Proscar®, used to treat benign prostate enlargement. 3

Table 1 - Summary of Key Randomized Studies of Beta-Sitosterol in BPH Patients.

Effects of beta-sitosterol on the International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), and post-void residual volume (PVR) are remarkably consistent. The study by Wilt and colleagues7 examined four different randomized studies.

Two years later, a review of all existing studies of beta-sitosterol in the treatment of benign prostate enlargement was conducted. The researchers identified randomized, placebo-controlled, double-blind trials involving a total of 519 men. In three of the trials, beta-sitosterol was used, and in one trial, a glucoside of beta-sitosterol was used. In these studies, beta-sitosterol improved urinary symptom scores and urinary flow rates, and significantly reduced the volume of residual urine in the bladder. 4,5 Table 1 summarizes some of the randomized studies of beta-sitosterol in the treatment of BPH.

The magnitude of reduction in prostate symptoms and improvement in urinary flow rates is a strong incentive for the use of beta-sitosterol, either alone or in combination with standard pharmacologic interventions such as alpha-adrenergic blockers (Cardura®, Hytrin®, Uroxatral®, Flomax®) or 5-alpha reductase inhibitors (Proscar®, Avodart®).

Beta-Sitosterol and Prostate Cancer

A study using the prostate cancer cell line LNCaP (an androgen dependent tumor) showed that beta-sitosterol decreased cancer cell growth by 24% and induced apoptosis (programmed cell death) four-fold. These findings were correlated with a 50% increase in ceramide production. 6 Research suggests that ceramide, an important component of the cell membrane, induces apopotosis. 7

Figure 2 - Effects of Phytosterol (Beta-Sitosterol + Campesterol) Mixture on PC-3 Cancer Cell Behavior.

The phytosterol mixture significantly reduced PC-3 cell growth, invasiveness, migration, and binding, compared to cholesterol. 10

Growth of the human prostate cancer PC-3 cell line (androgen independent) implanted in mice was compared in two groups receiving either a 2% phytosterol mixture or a cholesterol mixture. In the in vitro studies, both beta-sitosterol and campesterol inhibited the growth of PC-3 cells by 70% and 14%, respectively. Cholesterol supplementation, by contrast, increased the growth by 18% when compared with controls. 8

Phytosterols inhibited the invasion of PC-3 cells into Matrigel-coated membranes by 78% (a measure of cancer invasiveness), while cholesterol increased it by 43% compared to the cells in the control media. 8

Migration of tumor cells through 8-micron pore membranes (a measure of tumor motility) was reduced by 60-93% when the PC-3 cells were in phytosterol media, compared to a 67% increase after cholesterol supplementation. 8

Phytosterol supplementation reduced the binding of PC-3 cells to laminin by 15-38% and to fibronectin by 23%, while cholesterol increased binding to type IV collagen (a measure of adhesiveness and ability to form tumor clumps) by 36%. 8 The results are presented in Figure 2.

Table 2 - Tumor Cell Lines and Effects of Phytosterols.

Breast, prostate, and colon cancer cell lines showed significant decreases in cancer cell growth and tumor size after phytosterol administration. Metastases to lymph nodes and lungs were also decreased.

The researchers concluded that phytosterol indirectly (in vivo as a dietary supplement) and directly (in tissue culture media) inhibited the growth and metastasis of PC-3 cells. Beta-sitosterol was more effective than campesterol in offering this protection in most of the parameters studied. 8 Results of this study and other cell line trials involving phytosterols in cancer are shown in Table 2 shown on this page.

Conclusion

As men grow older, cells in their prostate glands often overgrow, causing a swelling that obstructs the bladder opening, resulting in slowness in urination and bladder emptying. This non-malignant enlargement of the prostate gland causes pressure on the urethra, acting like a clamp. The result is a weak urinary stream, hesitancy, and other uncomfortable urinary symptoms such as increased nighttime frequency and urgency. See Figure 3.

Figure 3 - Increasing Prevalence of Lower Urinary Tract Symptoms (LUTS) with Advancing Age.

As men age, the prevalence of LUTS increases as a reflection of prostate enlargement. 2

While a man aged 31 to 40 has only an 8% chance of having benign prostate enlargement, the risk increases to 40-50% in men aged 51 to 60 and to over 80% in men older than 80. 14

For millions of men in America, benign prostate enlargement will severely downgrade their quality of life. Yet across the ocean are drugs that have been shown in carefully controlled studies to alleviate much of the discomfort associated with prostate gland overgrowth.

Europeans use beta-sitosterol by itself or in combination with saw palmetto to alleviate urinary symptoms of benign prostate enlargement.

As the word gets out about the documented benefits of beta-sitosterol, American consumers can expect to see more prostate support products that contain this low-cost plant sterol.

There are dozens and dozens of older classic double blind studies done with real men on the effects of beta-sitosterol on benign prostate hypertrophy or BPH. Below we have summarized some of these studies . . . all of which indicate that beta-sitosterol is a highly effective trreatment for BPH.

A most unique review of 31 years of studies was published in the volume 280 of the Journal of the American Medical Association (1998) where they chose 18 different trials involving 2,939 men in total who were treated for BPH with beta-sitosterol. They said after reviewing all these studies, "The evidence suggests that beta-sitosterol improves urologic symptoms and and flow measures."

One of the very best studies done was published in the British Journal of Urology, volume 80 (1997), at the University of Dresden. Drs. Klippel, Hilti and Schipp studied 177 men for 6 months who suffered from BPH. Half the men got a placebo and half got the prescription extract Azuprostat containing 130 mg of beta-sitosterol. They cited a full 32 references to substantiate their research. They carefully screened all the men and tested them extensively during the study. They concluded, "These results show that beta-sitosterol is an effective option in the treatment of BPH."

Another unique review in a different manner was done by Dr. Buck in the British Journal of Urology, volume 78 (1996). At the Department of Urology in Glasgow, Scotland he did a 12 page review of herbal therapy for the prostate including Harzol, Tadenan, Permixon, Strogen and Sabalux (all European prescription herbal extracts standardized for beta-sitosterol content). He documents his review with 59 published worldwide studies and discusses the biological basis of prostate illness. His conclusions of the efficacy of herbal treatment of prescription drugs and therapy are well founded certainly.

In the Lancet, vol 345 (1995) a very professional study was done at the University of Bochum in Herne, Germany by Dr. Berges and his associates. They used pure beta-sitosterol with 200 men half of whom received a placebo over the course of a year. They said, "Significant improvement in symptoms and urinary flow parameters show the effectiveness of beta-sitosterol in the treatment of BPH." This is clearly one of the most important and well done studies on prostate ever published.

In volume 55 of Current Therapeutic Research (1994) a study done at the University of Brussels, Belgium by Dr. Braeckman using Prostaserene (an extract standardized for beta-sitosterol) for a mere six weeks led him to conclude, "Traditional parameters for quantifying prostatism, such as the International Prostate Symptom Score, the quality of life score, urinary flow rates, residual urinary volume, and prostate size were found to be significantly improved after only 45 days of treatment. After 90 days of treatment, a majority of patients (88%) and treating physicians (88%) considered the therapy effective."

A study published in volume 21 of European Urology (1992), at the Institute of Clinical Medicine at the University of Rome, DiSilverio and his colleagues studied 35 men with BPH for 3 months and gave half of them a placebo (inert capsules). They concluded, "On the basis of these considerations, monotherapy with S. repens extract (beta-sitosterol extracted from saw palmetto) may be more favorably accepted, since on account of similar clinical results, when compared to the combination therapy cyproterone acetate plus tamoxifen..."

In the German journal Wiener Klinische Wochenschrift, volume 22 (1990) at eight different urological clinics in Europe 263 total patients with BPH were studied over a two month period. They were given either Tadenan (a Pygeum africanum extract standardized for beta-sitosterol content) or a placebo. This very extensive study compiled from different clinics and different doctors yet all agreed that, "Treatment with the Pygeum africanum extract led to a marked clinical improvement: a comparison of the quantitative parameters showed a significant difference between the Pygeum africanum group and the placebo group with respect to therapeutic response."

Again, in Minerva Urologica e Nefrologica, volume 39 (1987), Drs. Bassi et al at the University of Padova studied 40 men with BPH with and extract of Pygeum africanum with a high beta-sitosterol content. Half the men received a placebo and many parameters were measured for the two month study. They concluded, "The preliminary results demonstrate a significant improvement of the frequency, urgency, dysuria (difficult, painful urination) and urinary flow in patients treated with the active drug."

In the Italian journal Minerva Urologica e Nefrologica, volume 37 (1985), doctors at the University of Padova studied the effect of beta-sitosterol extract on 27 men with BPH. Dr. Tasca and his associates measured urine flow and other parameters in men ranging from ages 49 to 81 compared to men receiving a placebo.

In the journal Urolage A, volume 24 (1985) at the University of Basel, Switzerland, Dr. Vontobel and his colleagues studied a strong extract of nettles containing a high concentration of beta-sitosterol in a double blind study of 50 men for nine weeks. They said that the use of beta-sitosterols from nettles, "The evaluation of the objective parameters showed significant differences."

The British Journal of Clinical Pharmacology in volume 18 (1984) at the Hospital Ambroise in Paris, Champault and two other doctors did a classic double blind study with 110 men half of them getting a placebo. They concluded, "Thus as predicted by pharmacological and biochemical studies PA109 (4 tablets of Permixon daily) would therefore appear to be a useful therapeutic tool in the treatment of BPH."

In Medical Science Research, volume 16 (1983), Drs. Malini and Vanithakumari at the Institute of Medical Sciences in Madras, India studied the effect of beta-sitosterol on the fructose concentration of the prostate. Fructose is vital to the function of the prostate with regard to the androgenic hormones such as DHEA and testosterone. This was a very unique and thorough study lasting almost two months.

In volume 77 of the German journal Midizinische Klinik (1982) a study done at the Urological Clinik of Krankenhauser in Ludenscheid-Hellersen was performed on 23 patients. Dr. Szutrely gave the patients either Harzol (herbal extract standardized for beta-sitosterol content) or a placebo for patients with prostate enlargement over a two month period. They measured their prostates with ultrasound equipment before and after treatment. At the end he said, "Within the scope of a controlled double blind study to demonstrate the effect of conservative therapy of benign prostatic hyperplasia with Harzol, ultrasonic examination of the prostate adenoma (enlargement) was carried out on 23 patients before and after therapy with the trial preparation of a placebo. Within a two month treatment with Harzol there was a significant change in echo structure of the prostate adenoma, and this is interpreted as a reduction in the interstitial formation of oedema (swelling)."

In volume 98 of the German journal Fortschrifte Medizin (1980) at the Klinische Endokrinologie in Freiburg, Zahradnik and other doctors studied the beta-sitosterols taken from star grass sold as the prescription extract Harzol in regard to the development of prostate enlargement and prostaglandin levels. High prostaglandin levels support tumor growth.

These have been only a few of the many dozens of medical journal publications of studies taken place in some of the most important urological clinics around the world. These studies all indicate that beta-sitosterol is highly effective in reducing enlarged prostates in BPH patients as well as significantly decreasing their BPH symptoms.

References

1. Berges RR, Kassen A, Senge T. Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up. BJU Int. 2000 May;85(7):842-6.

2. Berges RR, Windeler J, Trampisch HJ, Senge T. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet. 1995 Jun 17;345(8964):1529-32.

3. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group. Br J Urol. 1997 Sep;80(3):427-32.

4. Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int. 1999 Jun;83(9):976-83.

5. Wilt T, Ishani A, MacDonald R, Stark G, Mulrow C, Lau J. Beta-sitosterols for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2000;(2):CD001043.

6. von Holtz RL, Fink CS, Awad AB. Beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells. Nutr Cancer. 1998;32(1):8-12.

7. Duan RD. Anticancer compounds and sphingolipid metabolism in the colon. In Vivo. 2005 Jan-Feb;19(1):293-300.

8. Awad AB, Fink CS, Williams H, Kim U. In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells. Eur J Cancer Prev. 2001 Dec;10(6):507-13.

9. Awad AB, Gan Y, Fink CS. Effect of beta-sitosterol, a plant sterol, on growth, protein phosphatase 2A, and phospholipase D in LNCaP cells. Nutr Cancer. 2000;36(1):74-8.

10. Awad AB, Downie A, Fink CS, Kim U. Dietary phytosterol inhibits the growth and metastasis of MDA-MB-231 human breast cancer cells grown in SCID mice. Anticancer Res. 2000 Mar;20(2A):821-4.

11. Awad AB, Downie AC, Fink CS. Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture. Int J Mol Med. 2000 May;5(5):541-5.

12. Awad AB, Williams H, Fink CS. Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells. Nutr Cancer. 2001;40(2):157-64.

13. Awad AB, Burr AT, Fink CS. Effect of resveratrol and beta-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells. Prostaglandins Leukot Essent Fatty Acids. 2005 Mar;72(3):219-26.

14. Glynn RJ, Campion EW, Bouchard GR, Silbert JE. The development of benign prostatic hyperplasia among volunteers in the Normative Aging Study. Am J Epidemiol. 1985 Jan;121(1):78-90.

What is Saw Palmetto?

Saw palmetto (also known as Serenoa Repens) is a low-growing, small palm tree with fanlike, fingery fronds and small berry-shaped fruits. Saw palmetto is native to and grows exclusively in the USA, primarily in Florida and near by vicinities.

Saw palmetto berries mainly consist of carbohydrates, phytosterols, fixed oils (free fatty acids and their glycerides), steroids, flavonoids, resin, pigment, tannin, and volatile oil. Saw palmetto has been reported to contain diuretic, urinary antiseptic, and anabolic properties.

Native Americans, such as Seminole Indians have been eating saw palmetto fruits for at least 12,000 years. Despite their pungent taste these Indians recognize saw palmetto fruits as both a food and medicine. The native Floridians prepared infusions of Saw palmetto berries to treat stomach ache and dysentery, and used the fruit for diuretic and sexual tonic.

Prostate Miracle® is 3,000 times more powerful than Saw Palmetto

Though saw palmetto has been used for centuries as a treatment for bph; and in 1908 was officially listed in the United States Pharmacopoeia as a medicine for urinary tract problems; it is very important to note that the amount of beta sitosterol contained in saw palmetto is a mere 1/3,000 of the amount contained in one caplet of Prostate Miracle®. You would have to consume over a pound of saw palmetto berries or over (200) 500 mg capsules of saw palmetto extract to get the equivalent amount of beta sitosterol contained in a single dosage of Prostate Miracle®.

The following exerpt from the ABC news website is based on a recent study published in the he New England Journal of Medicine:

Saw Palmetto Called Ineffective, but Many Doctors Say They'll Still Recommend It

By SIRI E. NILSSON Feb. 8, 2006

Saw palmetto, an over-the-counter herbal therapy used by more than 2 million men for symptoms of an enlarged prostate, may be no more effective than a placebo, according to a study published in this week's issue of The New England Journal of Medicine.

The study followed 225 men who had moderate-to-severe symptoms of an enlarged prostate, also known as benign prostatic hyperplasia, or BPH. Half of the men were given saw palmetto extract twice a day, and half were given an inactive medication, or placebo.

At the end of one year, the men taking saw palmetto showed no significant improvement in their symptoms, nor did the placebo group.

The findings were welcomed by some doctors who said they felt all along that saw palmetto didn't work. Dr. Jacques Carter, at Beth Israel Deaconess Medical Center in Boston, said he has observed in his own clinical practice that saw palmetto is virtually ineffective. "In nearly every instance, my patients reported little if any improvement of the symptoms on this supplement," Carter said.

And Dr. Carl Reese, at Pennsylvania State University College of Medicine, hopes the new finding can convince patients to stop spending money on saw palmetto. "Millions of dollars are spent each year by men on this product and it may not be of any benefit," said Reese. "This article will help the argument that they are wasting their money."

Saw Palmetto may actually be Harmful to your Prostate

Selenium Research

Excerpts from the following article (published by: LE Magazine November 2006) summarize the latest selenium research

Important Health Benefits from an Overlooked Trace Mineral

Copy by Julius G. Goepp, MD

When was the last time your doctor suggested that you supplement with selenium in an effort to prevent cancer? Scientists now know that this trace mineral has extraordinary value in fighting various cancers and other conditions involving oxidative stress and inflammation. 1,2

Doctors assume that we get enough selenium through plant foods. Unfortunately, in many places in America and the rest of the world, including China and Russia, the soil is badly depleted of its selenium content because of acid rain, which can dramatically change the chemical composition of the soil. As a result, soil acidification alters of the ability of the soil to bind with vital elements such as selenium for assimilation into edible plants.

Selenium’s Unique Biochemical Properties

What makes selenium unique? While scientists are still elucidating selenium’s role in a multitude of biochemical processes, one of its chief attributes is serving as a component of specific proteins called selenoproteins. Almost all of these proteins are active in the defense against reactive oxygen species (free radicals), which fuel numerous diseases and the aging process itself through their damaging effects on DNA and proteins.

Selenoproteins and their antioxidant products scavenge cell-damaging free radicals. Selenium is the only mineral nutrient that has its own DNA code, which instructs the body’s protein-synthesis “machinery” to incorporate selenium into its host proteins. Scientists interpret this unique attribute as evidence of selenium’s fundamental importance to virtually all living things on Earth. 3

Selenium is available from many dietary sources, including garlic, Brazil nuts, and certain vegetables; however, the amount of bioavailable selenium from these sources varies tremendously, depending on the soil and weather conditions where the plants are grown. 4 Foods containing selenium may also contain substances that limit selenium’s bioavailability. 5 Therefore, selenium supplementation is often recommended as a way to assure a dependable, bioavailable supply of this nutrient. 6

Selenium deficiency is increasingly associated with adverse health conditions and even life-threatening diseases. People who live in selenium-poor regions of the world suffer from dramatically increased rates of cancer, infections, and inflammatory diseases. 1,7-9 Fortunately, many of these conditions can be prevented and even reversed with selenium supplementation. 10-13

In this article, we will examine how oxidative stress can increase our vulnerability to inflammation, infection, cancer, and cardiovascular disease, and how selenium and the selenoproteins work to counteract oxidative stress, even in people without overt selenium deficiency.

Selenium Protects Against Oxidative Stress

Scientists now generally recognize that most disease processes produce their effects through chemically reactive molecules known as free radicals. Free radicals are composed mostly of reactive oxygen and nitrogen compounds. These reactive oxygen species initiate a destructive cycle fueled in part by the body’s own defense mechanisms. They disrupt the normal structure of proteins and the genetic information encoded in DNA. This damage always results in the release of potent chemical messengers called cytokines. Cytokines trigger the inflammatory response in tissues, signaling immune and inflammatory cells to swarm the affected area.

This inflammatory reaction activates powerful factors deep within cell nuclei—such as nuclear factor-kappa beta (NFkB). These factors “translate” infection and inflammation into the uncontrolled cell replication that produces cancer. 14

Strong evidence also suggests that NFkB and related compounds are involved in the conversion of oxidative damage, stress, and inflammation into the stimuli that produce atherosclerosis and cardiovascular disease. 15

Selenium not only scavenges reactive oxygen species before these free radicals can damage cells, but also regulates nuclear factor activities deep within the cells themselves. 16 For this reason, scientists now call selenium “one of the most promising agents” for the prevention and control of cancer. 17

Laboratory evidence also supports selenium’s role in protecting cardiac muscle from the effects of reduced blood flow, or ischemia. 18 Under the extreme oxidative stress triggered by a severe infection, selenium has been shown to enhance the protective ability of intracellular antioxidant systems that use glutathione. 19 Moreover, selenium specifically inhibits the activation of NFkB, which in turn inhibits the release of inflammatory cytokines. In fact, in laboratory studies, a reduction of selenium has been shown to increase levels of these inflammatory molecules. 20 Research also shows that by reducing NFkB activity, selenium prevents the activation of inflammatory cells that contribute to vascular disease in type II diabetes. 21

These laboratory findings underscore selenium’s promise in preventing and treating a wide array of human diseases, while reducing the cumulative oxidative damage that underlies many of the deleterious changes associated with aging. 22

Selenium Combats Inflammatory and Infectious Diseases

The recognition of selenium’s ability to prevent oxidative damage has fueled research into how selenium influences various chronic inflammatory conditions. For example, in a study of 70 patients with rheumatoid arthritis, selenium concentrations were found to be significantly lower than in a healthy population. When the subjects were given selenium or placebo for three months, the selenium-supplemented group showed fewer tender or swollen joints and less morning stiffness than did the control group. The supplemented patients also required less cortisone and nonsteroidal anti-inflammatory drugs (NSAIDs) than did the controls, and demonstrated a reduction in laboratory indicators of inflammation. No side effects of selenium supplementation were noted. 23

Selenium has shown great promise in the treatment of autoimmune thyroiditis as well. 24 In a recent study, 48 patients with elevated levels of an antibody to thyroid enzymes were given selenium daily for three months, while 40 patients received placebo. Serum levels of the antibody dropped significantly in the supplemented group compared to the placebo group, demonstrating that selenium suppressed the autoimmune attack on these patients’ thyroid glands. 25 Similar reductions in measures of autoimmune inflammatory response have been shown in other studies of selenium alone or in combination with other antioxidants. 26-28

Many other autoimmune conditions are associated with low selenium levels, including autoimmune hepatitis and diabetes. 29-32 Preliminary trials have demonstrated a protective effect of selenium supplementation against both hepatitis C and alcoholic hepatitis; both conditions involve a substantial inflammatory component that is thought to be mitigated by the actions of selenoproteins. 33,34

Severe infection imposes some of the most concentrated oxidative stress of all human diseases. Selenium has shown important benefits for those with septic shock, one of the most troubling killers of people with infections, compromised immune systems, or those confined to the hospital. Now known as systemic inflammatory response syndrome, or SIRS, overwhelming infection leads to runaway release of cytokines and other inflammatory mediators, ultimately causing a dramatic failure of multiple organs and bodily systems. 19 This condition, formerly known as “septic shock,” has yielded dramatically to the inclusion of selenium in treatment protocols, as evidenced by two remarkable studies published in 1999.

When 21 intensive-care patients with SIRS were given high-dose selenium (beginning at 535 mcg per day), their selenium and glutathione peroxidase levels normalized within three days; by contrast, selenium and glutathione peroxidase levels remained low in 21 control patients who received only “normal” amounts of selenium. Scores on a scale of physiological function were significantly better in the supplemented group than in the controls, and hemodialysis because of acute kidney failure was needed in only 3 of the 21 supplemented patients, compared to 9 of the 21 control patients. 35 A similar study of 34 children with SIRS demonstrated markedly elevated activity of antioxidant enzymes in the selenium-supplemented group, with markers of lipid peroxidation and cell membrane destruction falling dramatically compared to controls. 36

Selenium Shows Promise in Preventing Cancer

To date, more than 100 animal studies have investigated selenium’s effects on the mechanisms responsible for initiating cancer. In the overwhelming majority of these studies, selenium reduced tumor incidence and tissue changes that lead to cancer. 8,37 The high incidence of various cancers in selenium-deficient regions of the world strongly supports a cancer-preventive role for selenium in humans as well, and epidemiological studies have demonstrated reductions in the rates of, and mortality from, all cancers in populations receiving selenium supplementation. 38

Selenium Prevents and Slows Prostate Cancer

Additional studies of selenium’s effects in helping to prevent specific cancers have yielded results that are even more positive.

One of the most dramatic of these was the unexpected outcome of a study designed to examine selenium’s impact on skin cancer. 39 This study of 1,312 individuals who received 200 mcg of selenium daily or a placebo showed no effect against skin cancer, but demonstrated “striking” results in preventing prostate cancer, the most common cancer in American men. 40,41 The overall risk of prostate cancer was almost 50% lower in the supplemented group than in the controls, though the result was significant only in men who had relatively low prostate-specific antigen (PSA) levels and low initial selenium levels.

This result prompted a re-analysis of data from the SU.VI.MAX study, with a specific look at prostate cancer. 42 Within that group, 5,141 men took the selenium-containing supplement or placebo for eight years, and biochemical markers of prostate disease were measured at the beginning and end of the study. Overall, a slight reduction in prostate cancer risk was reported; however, among men who had normal PSA levels at the study’s outset, a significant risk reduction of nearly 50% was recorded.

A 2005 study focusing on selenium’seffects in preventing prostate cancer dramatically confirmed this protective effect. 43 Forty-eight patients with early prostate cancer took selenium, vitamin E, both L-selenomethionine and vitamin E, or a placebo for three to six weeks before undergoing prostatectomy (removal of the prostate). Levels of cancer markers were measured and compared with 29 healthy control subjects. The startling result was a change in classification from cancerous to healthy in the serum markers of disease in the men who took supplements compared to those who did not.

In addition to its clear role in preventing prostate cancer, selenium may slow the progression of already established prostate cancer. In a six-week trial, 37 men with prostate cancer and increasing PSA levels were given either a placebo or an antioxidant supplement containing selenium, plant estrogens, and other antioxidants. 44 In the supplemented group, male hormone levels (known to stimulate prostate cancer growth) were lower during treatment. In addition, free PSA levels rose during treatment with the placebo, but decreased during antioxidant supplementation.

These studies, along with recent findings that selenium is selectively concentrated in prostate tissue, 45 strongly support a role for selenium supplementation in both preventing and slowing the progression of prostate cancer.

Selenium Protects Against Lung Cancer

Lung cancer is the most common cause of cancer death in the world. 46 The previously mentioned skin cancer study also demonstrated that selenium supplementation reduced rates of lung and colorectal cancers. 39 Lung cancer is associated with antioxidative stress and low levels of antioxidants, including selenium. 47 A 1993 study demonstrated a 50% reduction in lung cancer occurrence in people with the highest dietary selenium intake compared to those with the lowest intake. 48 This finding is supported by a more recent study of more than 27,000 male smokers who were followed for nearly 15 years. In this study, researchers found that lung cancer risk was significantly lower in patients who had the highest intake of antioxidant vitamins and selenium. 49

Selenium supplementation was highly effective in preventing lung cancer in a region of China where very low natural selenium concentrations contribute to some of the world’s highest rates of lung cancer. Forty Chinese tin miners were randomly assigned to receive either 300 mcg of selenium or a placebo daily for one year. As expected, selenium blood levels rose dramatically in the supplemented miners, while serum levels of the antioxidant enzyme glutathione peroxidase increased by 156%. At the same time, levels of lipid peroxide (a measure of cell membrane damage that leads to cancer) were reduced by 75% in the supplemented group, and there was laboratory evidence of protection from DNA damage, another prerequisite for cancer formation. 50

Moreover, results from the US Nutritional Prevention of Cancer Trial demonstrated a statistically significant reduction in lung cancer incidence with selenium supplementation, with 200 mcg per day cutting the incidence of cancer by nearly 50%. 51 A later re-analysis with additional data showed the effect to be most significant in people with low baseline selenium levels, again suggesting that supplementation is preventive when initiated early. 37

Selenium Guards Against Colon Cancer

Selenium supplementation has also shown effectiveness in preventing colorectal cancer, the third most common cause of cancer death in the US. 52 Glutathione peroxidase, a selenium-containing antioxidant enzyme, is genetically defective in a significant percentage of patients with colon cancer. 53 Selenium actually activates the DNA repair mechanisms that help cells protect themselves against colon and other cancers, 54 while inducing programmed cell death (apoptosis) in cancerous tissue. 55 In an animal model of cancer, selenium-containing broccoli in the diet of laboratory rats protected the animals against chemically induced mammary and colon cancers. 56

After demonstrating that patients with colon cancer routinely have selenium deficiencies, and that levels of vital antioxidant enzymes could be increased with selenium supplementation, one research team concluded, “If prospective trials confirm that selenium supplementation reduces colon cancer incidence rates, it may be concluded that selenium supplementation should be recommended for patients at risk.” 57

Such confirmation is now beyond doubt. In a 1996 study of 44 patients with colon cancer, half were randomly assigned to receive selenium supplements and half were given a placebo. All the subjects had their tumors surgically removed, and all had abnormally low selenium levels at baseline. The selenium-supplemented patients demonstrated significant increases in anti-cancer immune system cells compared to levels in control patients, suggesting that selenium supplementation boosts cell-mediated immunity. 58

More dramatic, unexpected evidence of selenium’s cancer-preventive properties comes from a 2006 study. Seeking to determine the maximum tolerable dose of the anti-cancer drug irinotecan, researchers administered a massive dose of selenomethionine (containing 2200 mcg of selenium) to protect against the drug’s toxicity. 59 Selenium supplementation was begun one week before the first dose of irinotecan was administered to colon cancer patients who had previously not responded to chemotherapy. This small study of highly drug-resistant patients produced unexpected responses (one patient out of six showed a partial response to treatment) and disease stabilization. No adverse effects of the high dose were reported. The scientists recommended further study of high-dose selenomethionine to determine the most protective serum concentrations of selenium.

Conclusion

A review of recent research findings suggests that scientists have only begun to tap selenium’s potential as a vital antioxidant mineral.

As scientists continue to discover the many ways in which oxidative stress is related to inflammation and its destructive consequences—from atherosclerosis to prostate, lung, colon, and other cancers—the disease-preventive powers of selenium are likely to receive even greater scrutiny. For now, all health-conscious adults would be well advised to incorporate this vital mineral nutrient in their daily supplement regimen as part of a comprehensive disease-prevention program.

References

1. Chu FF, Esworthy RS, Doroshow JH. Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer. Free Radic Biol Med. 2004 Jun 15;36(12):1481-95.

2. El-Bayoumy K, Sinha R, Pinto JT, Rivlin RS. Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds. J Nutr. 2006 Mar;136(3 Suppl):864S-9S.

3. Gromer S, Eubel JK, Lee BL, Jacob J. Human selenoproteins at a glance. Cell Mol Life Sci. 2005 Nov;62(21):2414-37.

4. Dodig S, Cepelak I. The facts and controversies about selenium. Acta Pharm. 2004 Dec;54(4):261-76.

5. Finley JW. Bioavailability of selenium from foods. Nutr Rev. 2006 Mar;64(3):146-51.

6. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF. Effectiveness of seleniumsupplements in a low-selenium area of China. Am J Clin Nutr. 2005 Apr;81(4):829-34.

7. Knekt P, Marniemi J, Teppo L, Heliovaara M, Aromaa A. Is low seleniumstatus a risk factor for lung cancer? Am J Epidemiol. 1998 Nov 15;148(10):975-82.

8. Patterson BH, Levander OA. Naturally occurring seleniumcompounds in cancer chemoprevention trials: a workshop summary. Cancer Epidemiol Biomarkers Prev. 1997 Jan;6(1):63-9.

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FAQ's

What is BPH?

BPH is benign prostatic hypertrophy or enlargement. Almost 30 million American men suffer from this condition and over 1/2 of men have BPH by the time they reach the age of 50. After the age of 80, almost every man has it.

Why does the Prostate Increase in Size?

The prostate gland undergoes the process of enlargement because of certain hormonal changes and some nutritional deficiencies.

What is the Treatment for BPH?

The main treatment is surgical. A procedure called TURP (transurethral resection of the prostate) removes some of the prostate tissue to increase the opening for the flow of urine. Medications, such as Hytrin, Cardura and Proscar also improve some of the symptoms. Unfortunately, neither the surgery nor the medications really decrease the size of the prostate. That’s why any relief they provide is only temporary.

How Effective is Prostate Miracle®?

In clinical studies, the Prostate Miracle® was effective in 95% of patients. There was a significant reduction in symptoms and an actual decrease of the prostate size. No side effects were observed.

How Should I Use Prostate Miracle®?

The suggested usage of Prostate Miracle® is 1 tablet 2 times a day, with or without food. Some men experience noticeable improvement in just a few days, others in a few weeks, the average is about 30 days, while in others it may take up to 2 months - remember in some cases an enlarged prostate has been developing over many years. It is best to continue taking Prostate Miracle® even after the symptoms have improved. This will help maintain optimal prostate health.

I am a diabetic. Is it safe for me to take Prostate Miracle®?

Though the beta sitosterol used in Prostate Miracle® is extracted from sugar cane pulp, the extract is in fact "sugar free". Prostate Miracle® is completely safe for diabetics to use.

I take heart and blood pressure medication. Can I take Prostate Miracle®?

Prostate Miracle® is completely safe for heart patients or those taking blood pressure medication.

Does Prostate Miracle® have any drug interactions or contraindications

Prostate Miracle® is generally free of drug interactions, but one known exception is decongestants. Some men have actually experienced a temporary worsening of their urinary disfunction and dry mouth when taking Prostate Miracle® with decongestants. Though this interaction is rare, we do NOT recommend taking Prostate Miracle® while taking decongestants.

Can Prostate Miracle® help with my sexual dysfunction or decreased libido?

Yes Prostate Miracle® can and often does help increase sexual desire and performance. Because the prostate is part of the reproductive system, it shares the exact same nervous system as the other male sexual organs. And so an enlarged prostate can interfere with normal nerve conduction and can easily effect penile erection and function as well as libido and desire. As Prostate Miracle® works to decrease the size of your enlarged prostate . . . libido, sexual desire and performance typically improve.

I am confused. Which of your three prostate products (Prostate Miracle®, Estrogen Balance® or Pectin Plus®) is best for me?

It depends on your condition (and budget):

If you have BPH and want to take just one product, then Prostate Miracle® should be your first choice, since 95% of men get significant relief from their BPH symptoms using Prostate Miracle®.
If you are one of the 5% of men who's BPH does not respond to Prostate Miracle® then Estrogen Balance® would be a great alternative.
- BPH (in most men) is caused by DHT production. Prostate Miracle® inhibits the production of DHT, which is why it works for most men.
- BPH (in some men) is caused by "estrogen dominance". Estrogen Balance® inhibits the production of estrogen, which is why it works for those men.
- In many men . . . both elevated DHT levels and "estrogen dominance" contribute to their BPH condition, which is why both Prostate Miracle® and Estrogen Balance® taken together give significant relief to their BPH.
if you have Prostatitis: Estrogen Balance® should be your first choice
if your case of prostatitis is a secondary condition of BPH then Prostate Miracle® would be quite helpful as well.
If you have Prostate Cancer: Pectin Plus® should be your first choice, as it inhibits the metastasis of cancer.

The bottom line is that all three products are beneficial to every man's prostate health; and we do recommend all three products for maintaining optimal prostate health.

SUPPLEMENT FACTS

Each capsule contains:

300 mg Beta Sitosterol Complex
7.5 mg of Zinc (as Zinc Citrate)
100 mcg of Selenium (as Selenium Amino Acid Chelate)
1000 iu's mg of Vitamin D3

Other ingredients: 100% Vegetable capsule, Rice Flour, L-Leucine, Syloid®

60 capsules per bottle, 2 capsules per day

Looking for the caplet version? Send us a note during the order process or send us an email message by clicking here

Prostate Miracle® — As low as $15.95

The most common symptoms include:

The most common symptoms include:

Prostate Facts

Are you ready to wear diapers and/or never have sex again?

Fortunately, BPH sufferers do not have to resign themselves to such a drastic outcome. Nature has given us a natural remedy to support good prostate health.

Prostate Miracle® is a Natural, Highly Effective Treatment for BPH

Prostate Miracle® is effective in 95% of patients... WITH NO SIDE EFFECTS.

Prostate Miracle® May Help Prevent and Slow the Growth of Prostate Cancer

Prostate Wars

Not All Beta Sitosterol is created equally

Saw Palmetto and Pygeum Africanum are Useless

Saw Palmetto may actually be Harmful to your Prostate

Lycopene is a Fraud

Beta-Sitosterol and the Aging Prostate Gland

Measuring Symptoms of Prostate Enlargement

Remarkable Effects of Beta-Sitosterol

Figure 1 - International Prostate Symptom Scores (IPSS): Beta-Sitosterol vs. Placebo.

Benefits of Beta-Sitosterol Confirmed

Table 1 - Summary of Key Randomized Studies of Beta-Sitosterol in BPH Patients.

Beta-Sitosterol and Prostate Cancer

Figure 2 - Effects of Phytosterol (Beta-Sitosterol + Campesterol) Mixture on PC-3 Cancer Cell Behavior.

Table 2 - Tumor Cell Lines and Effects of Phytosterols.

Conclusion

Figure 3 - Increasing Prevalence of Lower Urinary Tract Symptoms (LUTS) with Advancing Age.

There are dozens and dozens of older classic double blind studies done with real men on the effects of beta-sitosterol on benign prostate hypertrophy or BPH. Below we have summarized some of these studies . . . all of which indicate that beta-sitosterol is a highly effective trreatment for BPH.

References

Prostate Miracle® is 3,000 times more powerful than Saw Palmetto

Saw Palmetto Called Ineffective, but Many Doctors Say They'll Still Recommend It

Saw Palmetto may actually be Harmful to your Prostate

Important Health Benefits from an Overlooked Trace Mineral

Selenium’s Unique Biochemical Properties

Selenium Protects Against Oxidative Stress

Selenium Combats Inflammatory and Infectious Diseases

Selenium Shows Promise in Preventing Cancer

Selenium Prevents and Slows Prostate Cancer

Selenium Protects Against Lung Cancer

Selenium Guards Against Colon Cancer

Conclusion

References

What is BPH?

Why does the Prostate Increase in Size?

What is the Treatment for BPH?

How Effective is Prostate Miracle®?

How Should I Use Prostate Miracle®?

I am a diabetic. Is it safe for me to take Prostate Miracle®?

I take heart and blood pressure medication. Can I take Prostate Miracle®?

Does Prostate Miracle® have any drug interactions or contraindications

Can Prostate Miracle® help with my sexual dysfunction or decreased libido?

I am confused. Which of your three prostate products (Prostate Miracle®, Estrogen Balance® or Pectin Plus®) is best for me?

The bottom line is that all three products are beneficial to every man's prostate health; and we do recommend all three products for maintaining optimal prostate health.